2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N6911
    Licorice-saponin H2 118441-85-3 99.72%
    Liquorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a type of triterpenoid oligosaccharide glycoside found in the Glycyrrhiza genus. Liquorice-saponin H2 accumulates more in the roots of licorice plants under salt stress conditions, suggesting that it may play a role in plant stress resistance.
    Licorice-saponin H2
  • HY-N6995
    Marrubiin 465-92-9 99.50%
    Marrubiin, isolated from Marrubium vulgare, exhibits vasorelaxant and antioedematogenic activity. Marrubiin alleviates diabetic symptoms in animals.
    Marrubiin
  • HY-N7079
    Erythorbic acid 89-65-6
    Erythorbic acid is an orally active compound. Erythorbic acid improves the radiation resistance of Listeria monocytogenes. Erythorbic acid can react with free radicals and reduce oxidative damage. Erythorbic acid has weak antiscorbic activity. Erythorbic acid can prevent oxidative discoloration in meat products.
    Erythorbic acid
  • HY-N7107
    Fenchyl alcohol 1632-73-1
    Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candida albicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer.
    Fenchyl alcohol
  • HY-N7501
    Isoformononetin 486-63-5 99.47%
    Isoformononetin is an analog of Daidzein (HY-N0019) and has immunoprotective effects. Isoformononetin inhibits the differentiation of Th17 and B-cells lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions.
    Isoformononetin
  • HY-N7515
    Pinocembrin chalcone 4197-97-1 98.74%
    Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes.
    Pinocembrin chalcone
  • HY-N8600
    7,8,3′,4′-Tetrahydroxyflavone 3440-24-2 98.45%
    7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC50 value of 10.488 µM.
    7,8,3′,4′-Tetrahydroxyflavone
  • HY-N8920
    Syringetin 4423-37-4 99.42%
    Syringetin, a flavonoid derivative, is associated with increased BMP-2 production. Syringetin stimulates osteoblast differentiation at various stages, from maturation to terminally differentiated osteoblasts.
    Syringetin
  • HY-N9331
    Cimicifugoside H-1 163046-73-9 99.83%
    Cimicifugoside H-1, a cyclolanostanol xyloside, is a major constituent of C. foetida L. extract. Cimicifugoside H-1 inhibits bone resorption and ovariectomy-induced bone loss.
    Cimicifugoside H-1
  • HY-NP192
    Sericin
    Sericin is an orally active globular protein produced by silkworm cocoons. Sericin inhibits the expression of COX2, iNOS, TLR4, MAPK and NF-κB; reduces the levels of IL-18, IL-1 and CCL2; antagonizes the activity of AChE; and downregulates the expression of Bcl-2. Sericin enhances the PI3K/AKT-mediated insulin signaling pathway. Sericin inhibits the activity of tyrosinase (Tyrosinase), scavenges ROS, chelates metal ions, and increases the levels of antioxidant enzymes. Sericin induces apoptosis and arrests the cell cycle. Sericin exhibits antibacterial, moisturizing, cardioprotective and anticoagulant properties. Sericin can be used in research related to type 2 diabetes, hyperlipidemia, obesity, Alzheimer's disease, colon cancer, peripheral nerve injury and ischemic myocardial infarction.
    Sericin
  • HY-P1072
    PHM-27 (human) 87403-73-4 99.09%
    PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism.
    PHM-27 (human)
  • HY-P1473
    Amylin (8-37), rat 138398-61-5 99.73%
    Amylin (8-37), rat is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin (8-37), rat is a weak amylin receptor (AMY) antagonist.
    Amylin (8-37), rat
  • HY-P1523
    Leptin (22-56), human 183598-56-3 99.90%
    Leptin (22-56), human is the fragment of leptin, mediated via several isoforms of receptors (Ob-Rs).
    Leptin (22-56), human
  • HY-P1628
    Ganirelix 124904-93-4 99.88%
    Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea.
    Ganirelix
  • HY-P2740
    Alcohol dehydrogenase, Saccharomyces cerevisiae 9031-72-5
    Alcohol dehydrogenase, Saccharomyces cerevisiae is a dimeric protein in the cytosol of cells. Alcohol dehydrogenase, the key enzyme for alcohol consumption in the body, is the highest expressed in the liver and participates in the detoxification mechanism of environmental alcohol.
    Alcohol dehydrogenase, Saccharomyces cerevisiae
  • HY-P2765
    Glycerol-3-phosphate dehydrogenase, rabbit muscle 9075-65-4
    Glycerol-3-phosphate dehydrogenase, rabbit muscle (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate to sn-glycerol 3-phosphate. Glycerol-3-phosphate dehydrogenase is a glycolytic enzyme and is responsible for the re-oxidation of NADH to NAD+ and energy supply.
    Glycerol-3-phosphate dehydrogenase, rabbit muscle
  • HY-P2822
    Phosphoglycerate kinase, yeast 9001-83-6
    Phosphoglycerate kinase (PGK), yeast is a monomeric glycolytic/gluconeogenic enzyme that can be found in Saccharomyces cerevisiae. Phosphoglycerate kinase, yeast catalyzes phosphoryl-group transfer from 1,3-bisphosphoglycerate to ADP to form 3-phosphoglycerate and ATP, binds 3PGA, ATP, and Mg2+, and adopts a closed conformation. Phosphoglycerate kinase, yeast is commonly used in biochemical research.
    Phosphoglycerate kinase, yeast
  • HY-P3102
    GLP-1(32-36)amide 1417302-71-6 98.44%
    GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.
    GLP-1(32-36)amide
  • HY-P4588
    (Glu17,21,24)-Osteocalcin (1-49) (human) 1927927-11-4 98.26%
    (Glu17,21,24)-Osteocalcin (1-49) (human) is a bone-specific protein involved in bone formation and glucose metabolism.
    (Glu17,21,24)-Osteocalcin (1-49) (human)
  • HY-Y1173
    Isethionic acid sodium salt 1562-00-1 99.88%
    Isethionic acid sodium salt is an endogenous metabolite.
    Isethionic acid sodium salt
Cat. No. Product Name / Synonyms Application Reactivity